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Medications that inhibit CYP2D6 activity, which include paroxetine and quinidine, could lead to decreased clearance of oxycodone which could lead to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Sufferers must be titrated to pain relief U

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